Professor Carol Pollock

Professor
Medicine, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T:+61 2 9926 7126
F:+61 2 9436 3719
E:

Publications

2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

2009

  
  • Panchapakesan, U., Pollock, C., Saad, S. Review article: importance of the kidney proximal tubular cells in thiazolidinedione-mediated sodium and water uptake. Nephrology. 2009; 14:298-301. [Abstract]
  • Saad, S., Agapiou, D., Chen, X., Stevens, V., Pollock, C. The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009; 24:1130-41. [Abstract]
  • Mather, A., Chen, X., McGinn, S., Field, M., Sumual, S., Mangiafico, S., Zhang, Y., Kelly, D., Pollock, C. High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta(1) secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway. The international journal of biochemistry & cell biology. 2009; 41:561-9. [Abstract]

2008

  
  • Holian, J., Qi, W., Kelly, D., Zhang, Y., Mreich, E., Pollock, C., Chen, X. The Role of Kruppel-like factor 6 in Transforming Growth Factor-Beta-1-induced Epithelial-Mesenchymal Transition of Proximal Tubule Cells. American journal of physiology. Renal physiology. 2008; 295:F1388-96. [Abstract]
  • Stevens, V., Saad, S., Poronnik, P., Fenton-Lee, C., Polhill, T., Pollock, C. The role of SGK-1 in angiotensin II-mediated sodium reabsorption in human proximal tubular cells. Nephrology, dialysis, transplantation. 2008; 23:1834-1843. [Abstract]
  • Langham, R., Kelly, D., Gow, R., Zhang, Y., Cox, A., Qi, W., Thai, K., Pollock, C., Christensen, P., Parving, H., Gilbert, R. Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control. Diabetologia. 2008; 51:668-674. [Abstract]
  • Wong, M., Suzuki, Y., Tanifuji, C., Akiba, H., Okumura, K., Sugaya, T., Yamamoto, T., Horikoshi, S., Tan, S., Pollock, C., Tomino, Y. Peritubular Ischemia Contributes More to Tubular Damage than Proteinuria in Immune-Mediated Glomerulonephritis. Journal of the American Society of Nephrology : JASN. 2008; 19:290-7. [Abstract]
  • Pollock, C., Johnson, D., Hörl, W., Rossert, J., Casadevall, N., Schellekens, H., Delage, R., De Francisco, A., Macdougall, I., Thorpe, R., Toffelmire, E. Pure red cell aplasia induced by erythropoiesis-stimulating agents. Clinical journal of the American Society of Nephrology. 2008; 3:193-199. [Abstract]
  • Qi, W., Chen, X., Poronnik, P., Pollock, C. Transforming growth factor-beta/connective tissue growth factor axis in the kidney. The international journal of biochemistry & cell biology. 2008; 40:9-13. [Abstract]

2007

  
  • Qi, W., Chen, X., Zhang, Y., Holian, J., Mreich, E., Gilbert, R., Kelly, D., Pollock, C. High glucose induces macrophage inflammatory protein-3{alpha} in renal proximal tubule cells via a transforming growth factor-{beta}1 dependent mechanism. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2007; 22:3147-53. [Abstract]
  • Qi, W., Chen, X., Gilbert, R., Zhang, Y., Waltham, M., Schache, M., Kelly, D., Pollock, C. High Glucose-Induced Thioredoxin-Interacting Protein in Renal Proximal Tubule Cells Is Independent of Transforming Growth Factor-{beta}1. The American journal of pathology. 2007; 171:744-54. [Abstract]
  • Pollock, C., Cooper, B., Harris, D. Early start peritoneal dialysis. Advances in chronic kidney disease. 2007; 14:e27-e34. [Abstract]
  • Pollock, C., Poronnik, P. Albumin transport and processing by the proximal tubule: physiology and pathophysiology. Current opinion in nephrology and hypertension. 2007; 16:359-364. [Abstract]
  • Qi, W., Chen, X., Twigg, S., Zhang, Y., Gilbert, R., Kelly, D., Pollock, C. The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology (Carlton, Vic.). 2007; 12:267-274. [Abstract]
  • Qi, W., Johnson, D., Vesey, D., Pollock, C., Chen, X. Isolation, propagation and characterization of primary tubule cell culture from human kidney. Nephrology (Carlton, Vic.). 2007; 12:155-159. [Abstract]
  • Macdougall, I., Johnson, D., Pollock, C. Erythropoiesis-stimulating agent hyporesponsiveness. NEPHROLOGY. 2007; 12:321-330. [Abstract]
  • Panchapakesan, U., Sumual, S., Pollock, C. Nanomedicines in the treatment of anemia in renal disease: focus on CERA (Continuous Erythropoietin Receptor Activator). International journal of nanomedicine. 2007; 2:33-38. [Abstract]
  • Stevens, V., Saad, S., Chen, X., Pollock, C. The interdependence of EGF-R and SGK-1 in fibronectin expression in primary kidney cortical fibroblast cells. The international journal of biochemistry & cell biology. 2007; 39:1047-1054. [Abstract]

2006

  
  • Qi, W., Chen, X., Holian, J., Mreich, E., Twigg, S., Gilbert, R., Pollock, C. Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. American journal of physiology. Renal physiology. 2006; 291:F1070-7. [Abstract]
  • Qi, W., Chen, X., Holian, J., Twigg, S., Gilbert, R., Pollock, C. Transforming growth factor-beta1 differentially mediates fibrosis and immunomodulation in kidney tubular cells. Nephrology Dialysis Transplantation. 2006; 21:32-32. [Abstract]
  • Hryciw, D., Ekberg, J., Ferguson, C., Lee, A., Wang, D., Parton, R., Pollock, C., Yun, C., Poronnik, P. Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds - Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5. Journal of Biological Chemistry. 2006; 281:16068-16077. [Abstract]
  • Qi, W., Chen, X., Polhill, T., Sumual, S., Twigg, S., Gilbert, R., Pollock, C. TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. American journal of physiology. Renal physiology. 2006; 290:F703-9. [Abstract]
  • Gilbert, R., Connelly, K., Kelly, D., Pollock, C., Krum, H. Heart failure and nephropathy: Catastrophic and interrelated complications of diabetes. Clinical Journal of the American Society of Nephrology. 2006; 1:193-208. [Abstract]
  • Qi, W., Chen, X., Twigg, S., Polhill, T., Gilbert, R., Pollock, C. Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney international. 2006; 69:989-95. [Abstract]
  • Hryciw, D., Ekberg, J., Pollock, C., Poronnik, P. CIC-5: A chloride channel with multiple roles in renal tubular albumin uptake. International Journal of Biochemistry & Cell Biology. 2006; 38:1036-1042. [Abstract]
  • Qi, W., Chen, X., Poronnik, P., Pollock, C. The renal cortical fibroblast in renal tubulointerstitial fibrosis. The international journal of biochemistry & cell biology. 2006; 38:1-5. [Abstract]
  • Hryciw, D., Ekberg, J., Pollock, C., Poronnik, P. ClC-5: A chloride channel with multiple roles in renal tubular albumin uptake. The international journal of biochemistry & cell biology. 2006; 38:1036-42. [Abstract]

2005

  
  • Pollock, C., Voss, D., Hodson, E., Crompton, C., , C. Nutrition and growth in kidney disease. Nephrology (Carlton, Vic.). 2005; 10 Suppl 5:S177-230. [Abstract]
  • Panchapakesan, U., Sumual, S., Pollock, C., Chen, X. PPARgamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. American journal of physiology. Renal physiology. 2005; 289:F1153-8. [Abstract]
  • Panchapakesan, U., Chen, X., Pollock, C. Drug insight: thiazolidinediones and diabetic nephropathy--relevance to renoprotection. Nature clinical practice. Nephrology. 2005; 1:33-43. [Abstract]
  • Pollock, C., McMahon, L. Haemoglobin. Nephrology (Carlton, Vic.). 2005; 10 Suppl 4:S108-15. [Abstract]
  • Saad, S., Stevens, V., Wassef, L., Poronnik, P., Kelly, D., Gilbert, R., Pollock, C. High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubule. Kidney international. 2005; 68:985-97. [Abstract]
  • Chalmers, J., MacMahon, S., Cooper, M., Ferrannini, E., Glasziou, P., Grobbee, D., Hamet, P., Harrap, S., Heller, S., Liu, L., Mancia, G., Marre, M., Mogensen, C., Neal, B., Pan, C., Patel, A., Poulter, N., Rodgers, A., Woodward, M., Collins, R., Holman, R., Sandercock, P., Sleight, P., Adams, M., Fulcher, G., Harrisberg, B., Mitchell, P., Pollock, C., Watson, J., Colman, S., Cormack, A., Flynn, S., Jayne, K., Joshi, R., Monaghan, H., Richens, A., Rodeghiero, C., Holloway, T., Gray, B., Milne, A., Adderkin, A., Bobbink, I., de Guise, D., Guertin, M., Ma, L., Reid, J., Stolk, R., Wen, W. ADVANCE - Action in Diabetes and Vascular Disease: patient recruitment and characteristics of the study population at baseline. Diabetic Medicine. 2005; 22:882-888. [Abstract]
  • Hryciw, D., Pollock, C., Poronnik, P. PKC-alpha-mediated remodeling of the actin cytoskeleton is involved in constitutive albumin uptake by proximal tubule cells. American journal of physiology. Renal physiology. 2005; 288:F1227-35. [Abstract]
  • Qi, W., Twigg, S., Chen, X., Polhill, T., Poronnik, P., Gilbert, R., Pollock, C. Integrated actions of transforming growth factor-beta(1) and connective tissue growth factor in renal fibrosis. American Journal of Physiology-Renal Physiology. 2005; 288:F800-F809. [Abstract]
  • Mcavoy, B., Fulcher, G., Amerena, J., Conner, G., Beltrame, J., Hankey, G., Keech, A., Lloyd, B., Neale, M., Pollock, C., Sudhir, K., Waltham, R., West, M., , P. An evidence based clinical aid for cardiovascular disease--what do GPs think?. Australian family physician. 2005; 34:297-8. [Abstract]
  • Hryciw, D., Ekberg, J., Lee, A., Lensink, ., Kumar, S., Guggino, W., Cook, D., Pollock, C., Poronnik, P. Nedd4-2 is required for constitutive albumin endocytosis in proximal tubule cells. Faseb Journal. 2005; 19:A1182-A1182. [Abstract]
  • Zafiriou, S., Stanners, S., Saad, S., Polhill, T., Poronnik, P., Pollock, C. Pioglitazone inhibits cell growth and reduces matrix production in human kidney fibroblasts. Journal of the American Society of Nephrology: JASN. 2005; 16:638-45. [Abstract]
  • Pollock, C. The impact of guidelines for the prevention of anemia on clinical outcome. Peritoneal dialysis international: journal of the International Society for Peritoneal Dialysis. 2005; 25 Suppl 3:S99-101. [Abstract]
  • Pollock, C. The development of encapsulating peritoneal sclerosis. Peritoneal dialysis international: journal of the International Society for Peritoneal Dialysis. 2005; 25 Suppl 3:S113-4. [Abstract]
  • Pollock, C. Pathogenesis of peritoneal sclerosis. The International journal of artificial organs. 2005; 28:90-6. [Abstract]

2004

  
  • Hryciw, D., Ekberg, J., Lee, A., Lensink, I., Kumar, S., Guggino, W., Cook, D., Pollock, C., Poronnik, P. Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. The Journal of biological chemistry. 2004; 279:54996-5007. [Abstract]
  • McGinn, S., Poronnik, P., Gallery, E., Pollock, C. The effects of high glucose and atorvastatin on endothelial cell matrix production. Diabetic medicine : a journal of the British Diabetic Association. 2004; 21:1102-7. [Abstract]
  • Panchapakesan, U., Pollock, C., Chen, X. The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells. American journal of physiology. Renal physiology. 2004; 287:F528-34. [Abstract]
  • Polhill, T., Saad, S., Poronnik, P., Fulcher, G., Pollock, C. Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure. American journal of physiology. Renal physiology. 2004; 287:F268-73. [Abstract]
  • Zafiriou, S., Stanners, S., Polhill, T., Poronnik, P., Pollock, C. Pioglitazone increases renal tubular cell albumin uptake but limits proinflammatory and fibrotic responses. Kidney international. 2004; 65:1647-53. [Abstract]
  • Polhill, T., Saad, S., Poronnik, P., Fulcher, G., Pollock, C. Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure. American Journal of Physiology: Renal Physiology. 2004; 287:268-273.
  • Pollock, C., McGinn, S., Poronnik, P., Gallery, E. A method for the isolation of glomerular and tubulointerstitial endothelial cells. Comparison of characteristics with HUVECs. Nephrology. 2004; 9:229-237.
  • Hryciw, D., Lee, E., Pollock, C., Poronnik, P. Molecular changes in proximal tubule function in diabetes mellitus. Clinical and experimental pharmacology & physiology. 2004; 31:372-9. [Abstract]
  • Pollock, C. Assays for the detection of antibodies against erythropoeitins. Dialysis and Transplantation. 2004; 33:530-542.
  • Field, M., Pollock, C., Harris, D. O Sistema Renal. Rio de Janeiro: Editora Guanabara Koogan S.A., 2004.
  • Cooper, B., Branley, P., Bulfone, L., Collins, J., Craig, J., Dempster, J., Fraenkel, M., Harris, A., Harris, D., Johnson, D., Kesselhut, J., Luxton, G., Pilmore, A., Pollock, C., Tiller, D., , I. The Initiating Dialysis Early and Late (IDEAL) study: study rationale and design. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2004; 24:176-81. [Abstract]
  • Cooper, B., Penne, E., Bartlett, L., Pollock, C. Protein malnutrition and hypoalbuminemia as predictors of vascular events and mortality in ESRD. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2004; 43:61-6. [Abstract]
  • Qi, W., Poronnik, P., Young, B., Jackson, C., Field, M., Pollock, C. Human cortical fibroblast responses to high glucose and hypoxia. Nephron. Physiology [electronic resource]. 2004; 96:p121-9. [Abstract]

2003

  
  • Lee, E., Pollock, C., Drumm, K., Barden, J., Poronnik, P. Effects of pathophysiological concentrations of albumin on NHE3 activity and cell proliferation in primary cultures of human proximal tubule cells. American journal of physiology. Renal physiology. 2003; 285:F748-57. [Abstract]
  • McGinn, S., Saad, S., Poronnik, P., Pollock, C. High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase. American journal of physiology. Endocrinology and metabolism. 2003; 285:E708-17. [Abstract]
  • McGinn, S., Poronnik, P., King, M., Gallery, E., Pollock, C. High glucose and endothelial cell growth: novel effects independent of autocrine TGF-beta 1 and hyperosmolarity. American journal of physiology. Cell physiology. 2003; 284:C1374-86. [Abstract]
  • Drumm, K., Lee, E., Stanners, S., Gassner, B., Gekle, M., Poronnik, P., Pollock, C. Albumin and Glucose effects on Cell Growth Parameters, Albumin Uptake and Na+/Ha-Exchanger Isoform 3 in OK Cells. Cellular Physiology And Biochemistry. 2003; 13:199-206.
  • Hryciw, D., Wang, Y., Devuyst, O., Pollock, C., Poronnik, P., Guggino, W. Cofilin interacts with CIC-5 and regulates albumin uptake in proximal tubule cell lines. Journal Of Biological Chemistry. 2003; 278(41):40169-40176.
  • Mifsud, S., Kelly, D., Zhang, Y., Pollock, C., Wilkinson-Berka, J., Gilbert, R., Qi, W. Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy. Nephron Physiology. 2003; 95:83-91.
  • Pollock, C. Bloody ascites in a patient after transfer from peritoneal dialysis to hemodialysis. Seminars in dialysis. 2003; 16:406-410. [Abstract]
  • Pollock, C. Treatment of diabetic nephropathy: electrolyte and acid-base disturbances. In: Management of Diabetic Nephropathy. London and New York: Martyin Dunitz: Taylor & Francis Group 2003. p. 163-176.
  • Cooper, B., Aslani, A., Ryan, M., Ibels, L., Pollock, C. Nutritional state correlates with renal function at the start of dialysis. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2003; 23:291-5. [Abstract]

Current national competitive grants*

2010

Organisational Change in Healthcare: Determinants of Effective Clinical Networks
Castaldi P, Elliott E, Scott A, Middleton S, Craig J, D'Este C, Paul C, McElduff P, Pollock C, Haines M, Redman S, Yano E, Watt H, Needham K
ARC Linkage Project ($292,000 over 3 years)

The Role of Toll-like Receptors in Diabetic Nephropathy
Chadban S, Pollock C, Wu H, Panchapakesan U
NHMRC Project Grant ($712,875 over 3 years)

2008

TGFbeta isoforms differentially regulate fibrosis and inflammation in diabetic nephropathy via KLF transcription factors
Pollock C, Chen X, Qi W
NHMRC Project Grant ($518,750 over 3 years)

2007

The role of peroxisome proliferator-activated receptor gamma in sodium transport in human proximal tubule cells
Pollock C, Saad S
NHMRC Project Grant ($544,500 over 3 years)

Initiating Dialysis Early and Late Trial
Pollock C, Harris D, Cooper B
NHMRC Project Grant ($662,053 over 3 years)

* Grants administered through the University of Sydney