2009

• Melrose, J., Burkhardt, D., Taylor, T., Dillon, C., Read, R., Cake, M., Little, C. Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2009; 18:479-89. [Abstract]
• Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. Activated Protein C Mediates a Healing Phenotype In Cultured Tenocytes. Journal of cellular and molecular medicine. 2009; 13:749-57. [Abstract]
• Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. Activation of cartilage matrix metalloproteinases by activated protein C. Arthritis and Rheumatism. 2009; 60:780-791. [Abstract]

2008

• Fitzgerald, J., Rich, C., Burkhardt, D., Allen, J., Herzka, A., Little, C. Evidence for articular cartilage regeneration in MRL/MpJ mice. Osteoarthritis and Cartilage. 2008; 16:1319-1326. [Abstract]
• Cake, M., Read, R., Edwards, S., Smith, M., Burkhardt, D., Little, C., Ghosh, P. Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. Journal of Orthopaedic Science. 2008; 13:514-523. [Abstract]
• Wilson, R., Belluoccio, D., Little, C., Fosang, A., Bateman, J. Proteomic characterization of mouse cartilage degradation in vitro. Arthritis and Rheumatism. 2008; 58:3120-3131. [Abstract]
• Melrose, J., Smith, S., Little, C., Moore, R., Vernon-Roberts, B., Fraser, R. Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2008; 17:1131-48. [Abstract]
• Fosang, A., Little, C. Drug insight: aggrecanases as therapeutic targets for osteoarthritis. Nature clinical practice. Rheumatology. 2008; 4:420-427. [Abstract]
• Smith, M., Cake, M., Ghosh, P., Schiavinato, A., Read, R., Little, C. Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Oxford, England). 2008; 47:1172-8. [Abstract]
• Melrose, J., Hayes, A., Whitelock, J., Little, C. Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues. BioEssays : news and reviews in molecular, cellular and developmental biology. 2008; 30:457-469. [Abstract]
• Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gillies, R., Dart, A., Sonnabend, D., Little, C. Modulation of aggrecan and ADAMTS expression in ovine tendinopathy induced by altered strain. Arthritis and rheumatism. 2008; 58:1055-1066. [Abstract]
• Melrose, J., Smith, S., Appleyard, R., Little, C. Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2008; 17:314-24. [Abstract]
• Melrose, J., Smith, S., Smith, M., Little, C. The use of Histochoice for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus. Biotechnic & Histochemistry. 2008; 83:47-53. [Abstract]
• Melrose, J., Fuller, E., Roughley, P., Smith, M., Kerr, B., Hughes, C., Caterson, B., Little, C. Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis research & therapy. 2008; 10:R79. [Abstract]
• Alini, M., Eisenstein, S., Ito, K., Little, C., Kettler, A., Masuda, K., Melrose, J., Ralphs, J., Stokes, I., Wilke, H. Are animal models useful for studying human disc disorders/degeneration?. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2008; 17:2-19. [Abstract]

2007

• Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2007; 16:2193-205. [Abstract]
• Young, A., Appleyard, R., Smith, M., Melrose, J., Little, C. Dynamic Biomechanics Correlate With Histopathology in Human Tibial Cartilage: A Preliminary Study. Clinical orthopaedics and related research. 2007; 462:212-20. [Abstract]
• Powell, A., Little, C., Hughes, C. Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system. Arthritis and rheumatism. 2007; 56:3010-3019. [Abstract]
• Little, C., Meeker, C., Golub, S., Lawlor, K., Farmer, P., Smith, S., Fosang, A. Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. The Journal of clinical investigation. 2007; 117:1627-1636. [Abstract]

2006

• Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis research & therapy. 2006; 8:R41. [Abstract]

2005

• Stewart, M., Fosang, A., Little, C., Sandy, J. A murine epiphyseal chondrocyte model of ADAMTS 5-mediated aggrecanolysis. Journal of Bone and Mineral Research. 2005; 20:S200-S200. [Abstract]
• Little, C., Meeker, C., Hembry, R., Sims, N., Lawlor, K., Golub, S., Last, K., Fosang, A. Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development. Molecular and cellular biology. 2005; 25:3388-99. [Abstract]
• Stanton, H., Rogerson, F., East, C., Golub, S., Lawlor, K., Meeker, C., Little, C., Last, K., Farmer, P., Campbell, I., Fourie, A., Fosang, A. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature. 2005; 434:648-52. [Abstract]
• Little, C., Flannery, C., Hughes, C., Goodship, A., Caterson, B. Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2005; 13:162-70. [Abstract]
• Young, A., Smith, M., Smith, S., Burkhardt, D., Cake, M., Melrose, J., Read, R., Ghosh, P., Sonnabend, D., Little, C. Small leucine-rich proteoglycans in an ovine model of osteoarthritis. Orthopaedic Research Society. Transactions of the Annual Meeting. 2005; 30:1057.
• Young, A., Smith, M., Smith, S., Cake, M., Ghosh, P., Read, R., Melrose, J., Sonnabend, D., Roughley, P., Little, C. Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis research & therapy. 2005; 7:R852-61. [Abstract]
• Stanton, H., East, C., Golub, S., Rogerson, F., Lawlor, K., Little, C., Fosang, A. Adamts-5 is the major aggrecanase in cartilage: in vitro studies with adamts-4 and adamts-5 deficient mice. Transactions Orthopaedic Research Society. 2005; 30:206.
• Little, C., Meeker, C., Fosang, A. Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD. Orthopaedic Research Society. Transactions of the Annual Meeting. 2005; 30:357.
• Fosang, A., Little, C., Meeker, C. Aggrecan knock-in mice are resistant to proteolysis by MMP or ADAMTS enzymes in the interglobular domain. Scandinavian Journal of Rheumatology. 2005; 34:13-14.

2003

• Dart, A., Little, C., Hughes, C., Chu, O., Dowling, B., Hodgson, D., Rose, R., Johnson, K. Recombinant equine growth hormone administration: effects on synovial fluid biomarkers and cartilage metabolism in horses. Equine veterinary journal. 2003; 35:302-7. [Abstract]