Dr Sue Mei Firth

Senior Lecturer and Head, Protein Structure-Function Laboratory, Hormones and Cancer Group
Medicine, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T:+61 2 9926 4707
F:+61 2 9926 5908
E:

Publications

2007 | 2006 | 2005 | 2004 | 2003

2007

  
  • Schedlich, L., Graham, L., O'han, M., Muthukaruppan, A., Yan, X., Firth, S., Baxter, R. Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: Role in modulation of RAR-signaling. Archives of biochemistry and biophysics. 2007; 465:359-69. [Abstract]
  • Graham, M., Kilby, D., Firth, S., Robinson, P., Baxter, R. The in vivo phosphorylation and glycosylation of human insulin-like growth factor binding protein-5. Molecular & cellular proteomics : MCP. 2007; 6:1392-405. [Abstract]

2006

  
  • Fukunaga-Kalabis, M., Martinez, G., Liu, Z., Kalabis, J., Mrass, P., Weninger, W., Firth, S., Planque, N., Perbal, B., Herlyn, M. CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1. The Journal of cell biology. 2006; 175:563-9. [Abstract]
  • Yan, X., Baxter, R., Perbal, B., Firth, S. The aminoterminal insulin-like growth factor (IGF) binding domain of IGF binding protein-3 cannot be functionally substituted by the structurally homologous domain of CCN3. Endocrinology. 2006; 147:5268-74. [Abstract]
  • Santer, F., Bacher, N., Moser, B., Morandell, D., Ressler, S., Firth, S., Spoden, G., Sergi, C., Baxter, R., Jansen-Dürr, P., Zwerschke, W. Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis. Cancer research. 2006; 66:3024-33. [Abstract]

2005

  
  • Chan, S., Twigg, S., Firth, S., Baxter, R. Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes. The Journal of clinical endocrinology and metabolism. 2005; 90:6588-95. [Abstract]

2004

  
  • Yan, X., Forbes, B., McNeil, K., Baxter, R., Firth, S. Role of N- and C-terminal residues of insulin-like growth factor (IGF)-binding protein-3 in regulating IGF complex formation and receptor activation. The Journal of biological chemistry. 2004; 279:53232-40. [Abstract]
  • Payet, L., Firth, S., Baxter, R. The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers. The Journal of clinical endocrinology and metabolism. 2004; 89:2382-9. [Abstract]
  • Scott, C., Firth, S. The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?. Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme. 2004; 36:261-71. [Abstract]
  • Butt, A., Martin, J., Dickson, K., McDougall, F., Firth, S., Baxter, R. Insulin-like growth factor binding protein-3 expression is associated with growth stimulation of T47D human breast cancer cells: the role of altered epidermal growth factor signaling. The Journal of clinical endocrinology and metabolism. 2004; 89:1950-6. [Abstract]

2003

  
  • Payet, L., Wang, X., Baxter, R., Firth, S. Amino- and carboxyl-terminal fragments of insulin-like growth factor (IGF) binding protein-3 cooperate to bind IGFs with high affinity and inhibit IGF receptor interactions. Endocrinology. 2003; 144:2797-806. [Abstract]
  • Kricker, J., Towne, C., Firth, S., Herington, A., Upton, Z. Structural and functional evidence for the interaction of insulin-like growth factors (IGFs) and IGF binding proteins with vitronectin. Endocrinology. 2003; 144(7):2807-2815.

Current national competitive grants*

2008

The role of the M6P/IGF-11 receptor in regulating cellular function
Scott C, Firth S
NHMRC Project Grant ($265,500 over 3 years)

2007

Proteolysis of binding protein complexes regulates IGF bioavailability
Firth S, Baxter R
ARC Discovery Projects ($234,000 over 3 years)

* Grants administered through the University of Sydney