Home / Our research / Opioids and Neuropathic Pain Laboratory 

Dr Peregrine Osborne

Senior Lecturer
Medicine, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T:9926 5539
E:

Research interests

Pain processing, neuropathic pain, and the molecular neuropharmacology of opioids and other analgesic drugs

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Publications

2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

2009

  
  • Kalous, A., Osborne, P., Keast, J. Spinal cord compression injury in adult rats initiates changes in dorsal horn remodeling that may correlate with development of neuropathic pain. The Journal of Comparative Neurology. 2009; 513:668-684. [Abstract]
  • Hamlin, A., McNally, G., Westbrook, R., Osborne, P. Induction of Fos proteins in regions of the nucleus accumbens and ventrolateral striatum correlates with catalepsy and stereotypic behaviours induced by morphine. Neuropharmacology. 2009; 56:798-807. [Abstract]

2008

  
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  • Chieng, B., Lee, D., Du, Y., Osborne, P., Christie, M., Massotte, D. Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells. Neuroreport. 2008; 19:1793-6. [Abstract]
  • Xu, S., Cheng, Y., Keast, J., Osborne, P. 17{beta}-Estradiol activates ER{beta} signalling and inhibits TRPV1 activation by capsaicin in adult rat nociceptor neurons. Endocrinology. 2008; 149:5540-8. [Abstract]

2007

  
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  • Marchant, N., Densmore, V., Osborne, P. Coexpression of prodynorphin and corticotrophin-releasing hormone in the rat central amygdala: Evidence of two distinct endogenous opioid systems in the lateral division. The Journal of comparative neurology. 2007; 504:702-715. [Abstract]
  • Kalous, A., Osborne, P., Keast, J. Acute and chronic changes in dorsal horn innervation by primary afferents and descending supraspinal pathways after spinal cord injury. The Journal of comparative neurology. 2007; 504:238-253. [Abstract]
  • Hamlin, A., McNally, G., Osborne, P. Induction of c-Fos and zif268 in the nociceptive amygdala parallel abstinence hyperalgesia in rats briefly exposed to morphine. Neuropharmacology. 2007; 53:330-43. [Abstract]

2006

  
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  • Chieng, B., Christie, M., Osborne, P. Characterization of neurons in the rat central nucleus of the amygdala: Cellular physiology, morphology, and opioid sensitivity. The Journal of comparative neurology. 2006; 497:910-27. [Abstract]

2005

  
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  • Buller, K., Hamlin, A., Osborne, P. Dissection of peripheral and central endogenous opioid modulation of systemic interleukin-1beta responses using c-fos expression in the rat brain. Neuropharmacology. 2005; 49:230-42. [Abstract]
  • Osborne, P., Halliday, G., Cooper, H., Keast, J. Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. Neuroscience. 2005; 131:671-81. [Abstract]

2004

  
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  • Bengtson, C., Lee, D., Osborne, P. Opposing electrophysiological actions of 5-HT on noncholinergic and cholinergic neurons in the rat ventral pallidum in vitro. Journal of neurophysiology. 2004; 92:433-43. [Abstract]
  • Hamlin, A., Buller, K., Day, T., Osborne, P. Effect of naloxone-precipitated morphine withdrawal on c-fos expression in rat corticotropin-releasing hormone neurons in the paraventricular hypothalamus and extended amygdala. Neuroscience letters. 2004; 362:39-43. [Abstract]

2003

  
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  • Kanjhan, R., Osborne, P., Ouyang, M., Keast, J. Postnatal maturational changes in rat pelvic autonomic ganglion cells: a mixture of steroid-dependent and -independent effects. Journal of neurophysiology. 2003; 89:315-323. [Abstract]

Current national competitive grants*

2005

Effects of estrogens on bladder pain
Keast J, Osborne P
National Institute of Diabetes and Digestive and Kidney Diseases (USA) Research Support ($1,613,635 over 5 years)

* Grants administered through the University of Sydney

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