Hormones and Cancer Division

The Hormones and Cancer group
Members of the Hormones and Cancer Group

Laboratories and their heads

Overview of research program

Cancer research, and research into hormonal (endocrine) diseases, have been major focusses of the Kolling Institute for over 20 years. The Hormones and Cancer Group formed in 2007 from the merging of research laboratories in Cancer Genetics, Functional Genomics and Growth Research. This reorganisation, following the appointment of Professor Bruce Robinson as Dean of the Faculty of Medicine, has united the Kolling’s major cancer research teams into a single group, providing new opportunities for interaction and collaboration. The new group’s research continues to have a strong endocrine focus, both in the cancer area (hormone-dependent cancers including breast and ovarian cancer, and cancers of endocrine organs such as thyroid, parathyroid and adrenal glands) and in areas unrelated to cancer, such as bone metabolism and endocrine actions of growth hormone and growth factors. In addition to our strong links to the hospital departments of Endocrinology and Oncology, our ongoing interactions with cancer surgeons, including the research training of junior surgeons, provide constant opportunities for the cross-fertilisation of the group's research between the laboratory and clinic.

Research outcomes

The new group's research continues the interests of its component laboratories, with the Cancer Genetics laboratories focussing on genetic studies in brain, adrenal and thyroid cancer; Functional Genomics concentrating on mechanisms of parathyroid and ovarian tumorigenesis; and Growth Research laboratories particularly involved in growth-regulatory mechanisms involving the insulin-like growth factors (IGFs), their binding proteins (IGFBPs), and other growth factor signalling pathways. The Laboratory for Cellular and Diagnostic Proteomics conducts proteomic discovery projects in the areas of both cancer (disease biomarkers in breast and pancreatic cancer) and endocrinology (proteomic responses to growth hormone administration).