Dr Christopher Vaughan

Clinical Senior Lecturer
Medicine, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T:9926 7249
F:9906 4079
E:

Publications

2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

2009

  
  • Wrigley, P., Jeong, H., Vaughan, C. Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. British Journal of Pharmacology. 2009; 157:371-380. [Abstract]

2008

  
  • Lau, B., Vaughan, C. Muscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal grey. Molecular pharmacology. 2008; 74:1392-8. [Abstract]
  • Drew, G., Mitchell, V., Vaughan, C. Glutamate spillover modulates GABAergic synaptic transmission in the rat midbrain periaqueductal grey via metabotropic glutamate receptors and endocannabinoid signaling. The Journal of Neuroscience. 2008; 28:808-815. [Abstract]
  • Vuong, L., Mitchell, V., Vaughan, C. Actions of N-arachidonyl-glycine in a rat neuropathic pain model. Neuropharmacology. 2008; 54:189-93. [Abstract]
  • Jeong, H., Chenu, D., Johnson, E., Connor, M., Vaughan, C. Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey. Molecular pain. 2008; 4:54-65. [Abstract]

2007

  
  • Mitchell, V., Greenwood, R., Jayamanne, A., Vaughan, C. Actions of the endocannabinoid transport inhibitor am404 in neuropathic and inflammatory pain models. Clinical and experimental pharmacology & physiology. 2007; 34:1186-1190. [Abstract]
  • Vaughan, C., Drew, G. Cellular actions of cannabinoids and opioids in descending analgesic systems. In: Neurotransmitters in the Antinociceptive Descending Pathway. Kerala: Research Signpost 2007. p. 83-96.
  • Succar, R., Mitchell, V., Vaughan, C. Actions of N-arachidonyl-glycine in a rat inflammatory pain model. Molecular pain. 2007; 3:24-24. [Abstract]

2006

  
  • Ekberg, J., Jayamanne, A., Vaughan, C., Aslan, S., Thomas, L., Mould, J., Drinkwater, R., Baker, M., Abrahamsen, B., Wood, J., Adams, D., Christie, M., Lewis, R. {micro}O-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103:17030-5. [Abstract]
  • Vaughan, C. Stressed-out endogenous cannabinoids relieve pain. Trends in pharmacological sciences. 2006; 27:69-71. [Abstract]
  • Jayamanne, A., Greenwood, R., Mitchell, V., Aslan, S., Piomelli, D., Vaughan, C. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. British journal of pharmacology. 2006; 147:281-8. [Abstract]

2005

  
  • Drew, G., Mitchell, V., Vaughan, C. Postsynaptic actions of substance P on rat periaqueductal grey neurons in vitro. Neuropharmacology. 2005; 49:587-95. [Abstract]
  • Mitchell, V., Aslan, S., Safaei, R., Vaughan, C. Effect of the cannabinoid ajulemic acid on rat models of neuropathic and inflammatory pain. Neuroscience letters. 2005; 382:231-5. [Abstract]
  • Connor, M., Vaughan, C. Humanizing mice: catching up with elusive B1 receptors. British journal of pharmacology. 2005; 144:885-6. [Abstract]
  • Bagley, E., Gerke, M., Vaughan, C., Hack, S., Christie, M. GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron. 2005; 45:433-45. [Abstract]
  • Marinelli, S., Connor, M., Schnell, S., Christie, M., Wessendorf, M., Vaughan, C. delta-opioid receptor-mediated actions on rostral ventromedial medulla neurons. Neuroscience. 2005; 132:239-44. [Abstract]
  • Vaughan, C., Christie, M. Retrograde signalling by endocannabinoids. In: Handbook of Experimental Pharmacology. Heidelberg: Springer 2005. p. 367-384.

2004

  
  • Marinelli, S., Schnell, S., Hack, S., Christie, M., Wessendorf, M., Vaughan, C. Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. Journal of neurophysiology. 2004; 92:3532-7. [Abstract]
  • Connor, M., Bagley, E., Mitchell, V., Ingram, S., Christie, M., Humphrey, P., Vaughan, C. Cellular actions of somatostatin on rat periaqueductal grey neurons in vitro. British journal of pharmacology. 2004; 142:1273-80. [Abstract]
  • Drew, G., Vaughan, C. Multiple metabotropic glutamate receptor subtypes modulate GABAergic neurotransmission in rat periaqueductal grey neurons in vitro. Neuropharmacology. 2004; 46:927-34. [Abstract]
  • Gavioli, E., Vaughan, C., Marzola, G., Guerrini, R., Mitchell, V., Zucchini, S., De Lima, T., Rae, G., Salvadori, S., Regoli, D., Calo', G. Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice. Naunyn-Schmiedeberg''s archives of pharmacology. 2004; 369:547-53. [Abstract]
  • Christie, M., Vaughan, C. Mechanismen der Cannabinoidanalgesie. In: Cannabis und Cannabinoide. Bern: Verla Hans Huber 2004. p. 115-125.

2003

  
  • Hack, S., Vaughan, C., Christie, M. Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro. Neuropharmacology. 2003; 45:575-84. [Abstract]
  • Mitchell, V., Christie, M., Vaughan, C. Developmental changes in the alpha-adrenergic responses of rat periaqueductal grey neurons. Neuroreport. 2003; 14:1637-9. [Abstract]
  • Vaughan, C., Bagley, E., Drew, G., Schuller, A., Pintar, J., Hack, S., Christie, M. Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. British journal of pharmacology. 2003; 139:362-7. [Abstract]
  • Jennings, E., Vaughan, C., Roberts, L., Christie, M. The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. The Journal of physiology. 2003; 548:121-9. [Abstract]
  • Vaughan, C., Connor, M. In search of a role for the morphine metabolite morphine-3-glucuronide. Anesthesia And Analgesia. 2003; 97:311-312.

Current national competitive grants*

2010

Mechanisms of serotonergic and triptan mediated analgesia within the midbrain
Vaughan C, Connor M, Jeong H
NHMRC Project Grant ($527,500 over 3 years)

2008

Effects of muscle inflammation on sensory neuron excitability
Connor M, Vaughan C
NHMRC Project Grant ($408,500 over 3 years)

2007

Cellular mechanisms of endogenous cannabinoid mediated analgesia within the midbrain.
Vaughan C
NHMRC Project Grant ($499,500 over 3 years)

* Grants administered through the University of Sydney