Professor Robert Baxter

Professor and Director, Kolling Institute of Medical Research
Medicine, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T:+61 2 9926 4730
F:+61 2 9926 8484
E:

Publications

2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

2009

  
  • Chung, L., Nelson, A., Ho, K., Baxter, R. Proteomic profiling of growth hormone responsive proteins in human peripheral blood leukocytes. The Journal of clinical endocrinology and metabolism. 2009; 94:3038-43. [Abstract]
  • Chung, L., Baxter, R. Detection of growth hormone responsive proteins using SELDI-TOF mass spectrometry. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2009; 19:383-7. [Abstract]
  • Gosby, A., Stanton, L., Maloney, C., Thompson, M., Briody, J., Baxter, R., Bryson, J., Denyer, G., Caterson, I. Postnatal nutrition alters body composition in adult offspring exposed to maternal protein restriction. The British journal of nutrition. 2009; 101:1878-84. [Abstract]
  • Chan, S., Schedlich, L., Twigg, S., Baxter, R. Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3. American Journal of Physiology: Endocrinology and Metabolism. 2009; 296:E654-E663. [Abstract]

2008

  
  • Nguyen, T., Nelson, A., Howe, C., Seibel, M., Baxter, R., Handelsman, D., Kazlauskas, R., Ho, K. Within-Subject Variability and Analytic Imprecision of Insulin-Like Growth Factor Axis and Collagen Markers: Implications for Clinical Diagnosis and Doping Tests. Clinical chemistry. 2008; 54:1268-76. [Abstract]
  • Nelson, A., Meinhardt, U., Hansen, J., Walker, I., Stone, G., Howe, C., Leung, K., Seibel, M., Baxter, R., Handelsman, D., Kazlauskas, R., Ho, K. Pharmacodynamics of GH abuse biomarkers and the influence of gender and testosterone: a randomized double-blind placebo-controlled study in young recreational athletes. The Journal of clinical endocrinology and metabolism. 2008; 93:2213-22. [Abstract]
  • Marsh, D., Trahair, T., Martin, J., Chee, W., Walker, J., Kirk, E., Baxter, R., Marshall, G. Rapamycin treatment for a child with germline PTEN mutation. Nature clinical practice. Oncology. 2008; 5:357-61. [Abstract]
  • Chuang, S., Patton, K., Schafernak, K., Papavero, V., Lin, F., Baxter, R., Teh, B., Yang, X. Over expression of insulin-like growth factor binding protein 3 in clear cell renal cell carcinoma. The Journal of Urology. 2008; 179:445-449. [Abstract]
  • Baxter, R. Insulin-like Growth Factors and Tumor Hypoglycemia. In: Clinical Endocrine Oncology. United States: Wiley-Blackwell 2008. p. 576-581.

2007

  
  • Schedlich, L., Muthukaruppan, A., O'han, M., Baxter, R. Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the Vitamin D response in osteoblasts. Molecular endocrinology (Baltimore, Md.). 2007; 21:2378-90. [Abstract]
  • Schedlich, L., Graham, L., O'han, M., Muthukaruppan, A., Yan, X., Firth, S., Baxter, R. Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: Role in modulation of RAR-signaling. Archives of biochemistry and biophysics. 2007; 465:359-69. [Abstract]
  • Scarlett, C., Samra, J., Xue, A., Baxter, R., Smith, R. Classification of pancreatic cystic lesions using seldi-tof mass spectrometry. ANZ journal of surgery. 2007; 77:648-653. [Abstract]
  • Graham, M., Kilby, D., Firth, S., Robinson, P., Baxter, R. The in vivo phosphorylation and glycosylation of human insulin-like growth factor binding protein-5. Molecular & cellular proteomics : MCP. 2007; 6:1392-405. [Abstract]
  • Martin, J., Baxter, R. Expression of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway. Endocrinology. 2007; 148:2532-2541. [Abstract]
  • Baxter, R., Smith, R., Scarlett, C., Xue, A., Butturini, G., Scarpa, A. Hp07 proteomic identification of serum markers of pancreatic adenocarcinoma using seldi-tof ms. ANZ journal of surgery. 2007; 77:A41-A41. [Abstract]
  • Leong, S., Christopherson, R., Baxter, R. Profiling of Apoptotic Changes in Human Breast Cancer Cells Using SELDI-TOF Mass Spectrometry. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2007; 20:579-90. [Abstract]

2006

  
  • Yan, X., Baxter, R., Perbal, B., Firth, S. The aminoterminal insulin-like growth factor (IGF) binding domain of IGF binding protein-3 cannot be functionally substituted by the structurally homologous domain of CCN3. Endocrinology. 2006; 147:5268-74. [Abstract]
  • Nelson, A., Howe, C., Nguyen, T., Leung, K., Trout, G., Seibel, M., Baxter, R., Handelsman, D., Kazlauskas, R., Ho, K. Influence of demographic factors and sport type on growth hormone-responsive markers in elite athletes. The Journal of clinical endocrinology and metabolism. 2006; 91:4424-32. [Abstract]
  • Scarlett, C., Saxby, A., Nielsen, A., Bell, C., Samra, J., Hugh, T., Baxter, R., Smith, R. Proteomic profiling of cholangiocarcinoma: Diagnostic potential of SELDI-TOF MS in malignant bile duct stricture. Hepatology (Baltimore, Md.). 2006; 44:658-66. [Abstract]
  • Scarlett, C., Smith, R., Saxby, A., Nielsen, A., Samra, J., Wilson, S., Baxter, R. Proteomic classification of pancreatic adenocarcinoma tissue using protein chip technology. Gastroenterology. 2006; 130:1670-8. [Abstract]
  • Santer, F., Bacher, N., Moser, B., Morandell, D., Ressler, S., Firth, S., Spoden, G., Sergi, C., Baxter, R., Jansen-Dürr, P., Zwerschke, W. Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis. Cancer research. 2006; 66:3024-33. [Abstract]
  • Moscova, M., Marsh, D., Baxter, R. Protein chip discovery of secreted proteins regulated by the phosphatidylinositol 3-kinase pathway in ovarian cancer cell lines. Cancer research. 2006; 66:1376-83. [Abstract]
  • Chung, L., Clifford, D., Buckley, M., Baxter, R. Novel biomarkers of human growth hormone action from serum proteomic profiling using protein chip mass spectrometry. The Journal of clinical endocrinology and metabolism. 2006; 91:671-7. [Abstract]

2005

  
  • Moscova, M., Marsh, D., Baxter, R. Identification of Cytokines regulated by phosphatidylinositol-3 kinase in ovarian cancer. Clinical Cancer Research. 2005; 11:8977S-8977S. [Abstract]
  • Chan, S., Twigg, S., Firth, S., Baxter, R. Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes. The Journal of clinical endocrinology and metabolism. 2005; 90:6588-95. [Abstract]
  • Sevette, A., Smith, R., Aslani, A., Kee, A., Hansen, R., Barratt, S., Baxter, R. Does growth hormone allow more efficient nitrogen sparing in postoperative patients requiring parenteral nutrition? A double-blind, placebo-controlled randomised trial. Clinical nutrition (Edinburgh, Lothian). 2005; 24:943-55. [Abstract]
  • Nelson, A., Howe, C., Nguyen, T., Seibel, M., Baxter, R., Handelsman, D., Kazlauskas, R., Ho, K. Erythropoietin administration does not influence the GH--IGF axis or makers of bone turnover in recreational athletes. Clinical endocrinology. 2005; 63:305-9. [Abstract]
  • Brand-Miller, J., Liu, V., Petocz, P., Baxter, R. The glycemic index of foods influences postprandial insulin-like growth factor-binding protein responses in lean young subjects. The American journal of clinical nutrition. 2005; 82:350-4. [Abstract]
  • Butt, A., Dickson, K., Jambazov, S., Baxter, R. Enhancement of tumor necrosis factor-alpha-induced growth inhibition by insulin-like growth factor-binding protein-5 (IGFBP-5), but not IGFBP-3 in human breast cancer cells. Endocrinology. 2005; 146:3113-22. [Abstract]
  • Takahashi, M., Papavero, V., Yuhas, J., Kort, E., Kanayama, H., Kagawa, S., Baxter, R., Yang, X., Gray, S., Teh, B. Altered expression of members of the IGF-axis in clear cell renal cell carcinoma. International journal of oncology. 2005; 26:923-31. [Abstract]
  • Healy, M., Dall, R., Gibney, J., Bassett, E., Ehrnborg, C., Pentecost, C., Rosen, T., Cittadini, A., Baxter, R., Sonksen, P. Toward the development of a test for growth hormone (GH) abuse: A study of extreme physiological ranges of GH-dependent markers in 813 elite athletes in the postcompetition setting. Journal of Clinical Endocrinology and Metabolism. 2005; 90:641-649. [Abstract]

2004

  
  • Yan, X., Forbes, B., McNeil, K., Baxter, R., Firth, S. Role of N- and C-terminal residues of insulin-like growth factor (IGF)-binding protein-3 in regulating IGF complex formation and receptor activation. The Journal of biological chemistry. 2004; 279:53232-40. [Abstract]
  • Scarlett, C., O'leary, M., Kee, A., Nielsen, A., Sevette, A., Baxter, R., Smith, R. A study of parenteral versus enteral nutrition following caecal ligation and puncture in the rat: Influence on survival and tissue protein turnover. Clinical nutrition (Edinburgh, Lothian). 2004; 23:1135-45. [Abstract]
  • Mesotten, D., Wouters, P., Peeters, R., Hardman, K., Holly, J., Baxter, R., Van den Berghe, G. Regulation of the somatotropic axis by intensive insulin therapy during protracted critical illness. The Journal of clinical endocrinology and metabolism. 2004; 89:3105-13. [Abstract]
  • Payet, L., Firth, S., Baxter, R. The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers. The Journal of clinical endocrinology and metabolism. 2004; 89:2382-9. [Abstract]
  • Butt, A., Martin, J., Dickson, K., McDougall, F., Firth, S., Baxter, R. Insulin-like growth factor binding protein-3 expression is associated with growth stimulation of T47D human breast cancer cells: the role of altered epidermal growth factor signaling. The Journal of clinical endocrinology and metabolism. 2004; 89:1950-6. [Abstract]
  • Schedlich, L., O'Han, M., Leong, G., Baxter, R. Insulin-like growth factor binding protein-3 prevents retinoid receptor heterodimerization: implications for retinoic acid-sensitivity in human breast cancer cells. Biochemical and biophysical research communications. 2004; 314:83-8. [Abstract]

2003

  
  • Mesotten, D., Van den Berghe, G., Liddle, C., Coulter, S., McDougall, F., Baxter, R., Delhanty, P. Growth hormone modulation of the rat hepatic bile transporter system in endotoxin-induced cholestasis. Endocrinology. 2003; 144:4008-17. [Abstract]
  • Butt, A., Dickson, K., McDougall, F., Baxter, R. Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. The Journal of biological chemistry. 2003; 278:29676-85. [Abstract]
  • Payet, L., Wang, X., Baxter, R., Firth, S. Amino- and carboxyl-terminal fragments of insulin-like growth factor (IGF) binding protein-3 cooperate to bind IGFs with high affinity and inhibit IGF receptor interactions. Endocrinology. 2003; 144:2797-806. [Abstract]
  • Frystyk, J., Nyholm, B., Skjaerbaek, C., Baxter, R., Schmitz, O., Ørskov, H. The circulating IGF system and its relationship with 24-h glucose regulation and insulin sensitivity in healthy subjects. Clinical endocrinology. 2003; 58:777-84. [Abstract]
  • Schedlich, L., Nilsen, T., John, A., Jans, D., Baxter, R. Phosphorylation of insulin-like growth factor binding protein-3 by deoxyribonucleic acid-dependent protein kinase reduces ligand binding and enhances nuclear accumulation. Endocrinology. 2003; 144:1984-93. [Abstract]
  • Srinivasan, S., Waters, M., Rowland, J., Baxter, R., Verge, C. Hyperinsulinism and overgrowth without obesity. Archives of disease in childhood. 2003; 88:332-4. [Abstract]
  • Gunton, J., Delhanty, P., Takahashi, S., Baxter, R. Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2. The Journal of clinical endocrinology and metabolism. 2003; 88:1323-32. [Abstract]
  • Martin, J., Weenink, S., Baxter, R. Insulin-like growth factor-binding protein-3 potentiates epidermal growth factor action in MCF-10A mammary epithelial cells. Involvement of p44/42 and p38 mitogen-activated protein kinases. The Journal of biological chemistry. 2003; 278:2969-76. [Abstract]
  • Le Roith, D., Zumkeller, W., Baxter, R. Insulin-like Growth Factor Receptor Signalling. Netherlands: Kluwer, 2003.
  • Ehrnborg, C., Lange, K., Dall, R., Christiansen, J., Lundberg, P., Baxter, R., Boroujerdi, M., Bengtsson, B., Healey, M., Pentecost, C., Longobardi, S., Napoli, R., Rosén, T., , G. The growth hormone/insulin-like growth factor-I axis hormones and bone markers in elite athletes in response to a maximum exercise test. The Journal of clinical endocrinology and metabolism. 2003; 88:394-401. [Abstract]
  • Fanayan, S., Baxter, R. Functional relationships between transforming growth factor-beta and the insulin-like growth factor binding proteins. In: Insulin-Like Growth Factors. New York: Kluwer Academic/Plenum Publishers 2003. p. 281-293.

Current national competitive grants*

2010

Protein discovery for breast cancer diagnosis
Baxter R, Moore K, Marsh D, Boyle F, McCarthy N
NHMRC Project Grant ($397,125 over 3 years)

2009

How IGFBP-3 improves cancer cell responsiveness to DNA-damaging therapies
Baxter R
ARC Discovery Project ($480,000 over 3 years)

2007

Breast Cancer Tissue Bank
Clarke C, Baxter R, Bilous M, Boyages J, Carpenter J, Forbes J, Friedlander M, Harnett P, Kefford R, Marsh D, Morey A, Scott R, Spigelman A, Sutherland R, Balleine R
National Breast Cancer Foundation Project Grants ($1,455,090 over 5 years)

Novel regulators of fat cell differentiation
Twigg S, McLennan S, Baxter R
NHMRC Project Grant ($428,250 over 3 years)

Proteomic screening for apoptotic markers in cancer
Baxter R, Leong S, Christopherson R
NHMRC Project Grant ($511,500 over 3 years)

Proteolysis of binding protein complexes regulates IGF bioavailability
Firth S, Baxter R
ARC Discovery Projects ($234,000 over 3 years)

* Grants administered through the University of Sydney