Home / Our research / Sutton Arthritis Research Laboratory 

Associate Professor Chris John Jackson

Director, Sutton Laboratories
Medicine, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T:+61 2 9926 6043
F:+61 2 9926 6269
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Research interests

Dr Jackson's research focuses on cellular and molecular mechanisms of inflammation. We have a special interest in two groups of enzymes known as the matrix metalloproteinases and the serine proteases. Novel molecular biological techniques are used to manipulate cellular systems. Some interesting recent discoveries have come from our work investigating the mechanisms of action of one of these enzymes, activated protein C (APC). Our experiments using cultured cells and animal wounding models provide very strong evidence that APC accelerates wound healing. This work extends beyond cutaneous ulcers and has application to the healing of other tissues such as cartilage and bone that have been damaged by either disease, such as arthritis, or injury. Currently we are running 2 clinical trials to examine the efficacy of APC to treat chronic leg ulcers and burns.

Two provisional patent applications for new therapeutic interventions have arisen from work performed in the Sutton laboratories.

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Publications

2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

2009

  
  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. Activated Protein C Mediates a Healing Phenotype In Cultured Tenocytes. Journal of cellular and molecular medicine. 2009; 13:749-57. [Abstract]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. Activation of cartilage matrix metalloproteinases by activated protein C. Arthritis and Rheumatism. 2009; 60:780-791. [Abstract]
  • Xue, A., Xue, M., Jackson, C., Smith, R. Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. The international journal of biochemistry & cell biology. 2009; 41:1731-1738. [Abstract]

2008

  
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  • Whitmont, K., Reid, I., Tritton, S., March, L., Xue, M., Lee, M., Fulcher, G., Sambrook, P., Slobedman, E., Cooper, A., Jackson, C. Treatment of chronic leg ulcers with topical activated protein C. Archives of Dermatology. 2008; 144:1479-1483. [Abstract]
  • Xue, M., Jackson, C. Autocrine Actions of Matrix Metalloproteinase (MMP)-2 Counter the Effects of MMP-9 to Promote Survival and Prevent Terminal Differentiation of Cultured Human Keratinocytes. The Journal of investigative dermatology. 2008; 128:2676-85. [Abstract]
  • Jackson, C., Whitmont, K., Tritton, S., March, L., Sambrook, P., Xue, M. New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy. 2008; 8:1109-1122. [Abstract]
  • Xue, A., Scarlett, C., Jackson, C., Allen, B., Smith, R. Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma. Pancreas. 2008; 36:160-167. [Abstract]
  • Xie, L., Galettis, A., Morris, J., Jackson, C., Twigg, S., Gallery, E. Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes/metabolism research and reviews. 2008; 24:294-300. [Abstract]
  • Jackson, C., Xue, M. Activated protein C-An anticoagulant that does more than stop clots. The international journal of biochemistry & cell biology. 2008; 40:2692-7. [Abstract]

2007

  
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  • Xue, M., March, L., Sambrook, P., Fukudome, K., Jackson, C. Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Annals of the rheumatic diseases. 2007; 66:1574-80. [Abstract]
  • Xue, M., March, L., Sambrook, P., Jackson, C. Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: Relevance to inflammation in rheumatoid arthritis. Arthritis and rheumatism. 2007; 56:2864-74. [Abstract]
  • Xue, M., Campbell, D., Jackson, C. Protein C is an autocrine growth factor for human skin keratinocytes. The Journal of biological chemistry. 2007; 282:13610-13616. [Abstract]
  • Le, N., Xue, M., Castelnoble, L., Jackson, C. The dual personalities of matrix metalloproteinases in inflammation. Frontiers in bioscience : a journal and virtual library. 2007; 12:1475-1487. [Abstract]
  • Gallagher, G., Jackson, C., Hunyor, S. Myocardial extracellular matrix remodeling in ischemic heart failure. Frontiers in bioscience : a journal and virtual library. 2007; 12:1410-1419. [Abstract]
  • Gallagher, G., Menzie, S., Huang, Y., Jackson, C., Hunyor, S. Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction in sheep. Basic research in cardiology. 2007; 102:63-72. [Abstract]

2006

  
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  • Au, C., Luk, S., Jackson, C., Ng, H., Yow, C., To, S. Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. Journal of Photochemistry and Photobiology B-Biology. 2006; 85:92-101. [Abstract]
  • Xue, M., Le, N., Jackson, C. Targeting matrix metalloproteases to improve cutaneous wound healing. Expert opinion on therapeutic targets. 2006; 10:143-55. [Abstract]
  • Xue, M., Thompson, P., Sambrook, P., March, L., Jackson, C. Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clinical hemorheology and microcirculation. 2006; 34:153-61. [Abstract]

2005

  
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  • Xue, M., Campbell, D., Sambrook, P., Fukudome, K., Jackson, C. Endothelial protein C receptor and protease-activated receptor-1 mediate induction of a wound-healing phenotype in human keratinocytes by activated protein C. The Journal of investigative dermatology. 2005; 125:1279-85. [Abstract]
  • Jackson, C., Xue, M., Thompson, P., Davey, R., Whitmont, K., Smith, S., Buisson-Legendre, N., Sztynda, T., Furphy, L., Cooper, A., Sambrook, P., March, L. Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2005; 13:284-94. [Abstract]

2004

  
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  • Galettis, A., Campbell, S., Morris, J., Jackson, C., Twigg, S., Gallery, E. Monocyte adhesion to decidual endothelial cells is increased in pregnancies complicated by type 1 diabetes but not by gestational diabetes. Diabetes care. 2004; 27:2514-5. [Abstract]
  • Xue, M., Thompson, P., Kelso, I., Jackson, C. Activated protein C stimulates proliferation, migration and wound closure, inhibits apoptosis and upregulates MMP-2 activity in cultured human keratinocytes. Experimental cell research. 2004; 299:119-27. [Abstract]
  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. Interaction of cocultured decidual endothelial cells and cytotrophoblasts in preeclampsia. Biology of reproduction. 2004; 71:244-52. [Abstract]
  • Buisson-Legendre, N., Smith, S., March, L., Jackson, C. Elevation of activated protein C in synovial joints in rheumatoid arthritis and its correlation with matrix metalloproteinase 2. Arthritis and rheumatism. 2004; 50:2151-6. [Abstract]
  • Qi, W., Poronnik, P., Young, B., Jackson, C., Field, M., Pollock, C. Human cortical fibroblast responses to high glucose and hypoxia. Nephron. Physiology [electronic resource]. 2004; 96:p121-9. [Abstract]

2003

  
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  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. In vitro migration of cytotrophoblasts through a decidual endothelial cell monolayer: the role of matrix metalloproteinases. Placenta. 2003; 24:306-315. [Abstract]
  • Jackson, C., Schrieber, L. Angiogenesis in rheumatoid arthritis. In: Rheumatology: Third Edition. Edinburgh: Mosby 2003. p. 851-854.

Current national competitive grants*

2009

Novel pathways involving APC and PAR-2 in cartilage degradation in osteoarthritis
Little C, Jackson C
NHMRC Project Grants ($431,000 over 3 years)

2008

Activated protein C utilises protease activated receptors and epidermal growth factor receptor to heal wounds
Jackson C, Xue M
NHMRC Project Grant ($228,750 over 3 years)

* Grants administered through the University of Sydney

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